Table 1.
Patient characteristics
| Characteristics | All patients n = 58 (100%) |
EBV carrier state | p value | |
|---|---|---|---|---|
| CHL n = 14 (24%) |
Non-CHL n = 44 (76%) |
|||
| Age at renal transplantation; median, (range) (year) | 10 (1–17) | 2 (1–15) | 12 (2–17) | < 0.0001 |
| Boys/girls | 29/29 | 10/4 | 19/25 | 0.12 |
| Diagnosis: | ||||
| CAKUT | 25 | 10 (71%) | 15 (34%) | 0.021 |
| Hereditary disorders | 18 | 3 (22%) | 15 (34%) | |
| Acquired diseases | 13 | 1 (7%) | 12 (27%) | |
| Unknown | 2 | – | 2 (5%) | |
| No dialysis prior to tx | 23 | 5 (36%) | 18 (41%) | 0.98 |
| HLA mismatch 0–2 | 26 | 5 (36%) | 21 (48%) | |
| 3–4 | 23 | 8 (57%) | 15 (34%) | |
| 5–6 | 9 | 1 (7%) | 8 (18%) | 0.97 |
| Living donor | 44 | 13 (93%) | 31 (70%) | 0.17 |
| Cold ischemic time; median, (range) (h) | 2a (1–18) | 1.8a (1.3–9) | 2.1a (1–18) | 0.10 |
| Initial immunosuppressive regimen: | ||||
| Interleukin-2 receptor antagonist | 38 | 6 | 32 | |
| Cyclosporine A | 2 | 0 | 2 | |
| Tacrolimus | 56 | 14 | 42 | |
| Mycophenolate mofetil | 58 | 14 | 44 | |
| Corticosteroids | 58 | 14 | 44 | |
| GFR; median (range) (ml/min/1.73 m2) | ||||
| 3 months after tx | 69 (25–114) | 82 (51–114) | 67 (25–103) | 0.0016 |
| 1 year after tx | 69b (39–109) | 76 (53–109) | 67b (39–96) | 0.19 |
| Post-tx follow-up time; median, (range) (year) | 3.7 (0.4–13) | 7.8 (0.7–13) | 2.9 (0.4–11) | |
| Rejection | 16 | 3 | 13 | 0.83 |
| Second renal transplantation | 1 | 1 | 0 | |
| Ad mortem | 1 | 0 | 1 | |
Values are expressed as number (%), unless specified. For categorical variables, n (%) is presented. For continuous variables median (min; max)/ is presented. For comparison between groups, Fisher’s exact test (lowest one-sided p value multiplied by 2) was used for dichotomous variables and the Mantel-Haenszel chi-square test was used for ordered categorical variables and chi-square test was used for non-ordered categorical variables and the Mann-Whitney U test was used for continuous variables.
CHL chronic high load, non-CHL non-chronic high load consisting of low viral load (LVL) and undetectable viral load (UVL), CAKUT congenital anomalies of the kidney and urinary tract, GFR glomerular filtration rate, tx transplantation
aCold ischemic time for four patients were lacking (n = 54), two patients in the CHL group (n = 12) and two in the non-CHL group (n = 42)
bGFR-data for one patient at 1 year post-transplant missing because deceased (n = 57 in all patients and n = 43 in non-CHL)