Table 2.
Patients with initial test results indicating adrenal insufficiency with normal adrenal function during follow-up
| No. | Sex | Age (years) | Diagnosis | BC (nmol/L) | CRH-peak cortisol (nmol/L) | HC after surgery (y/n) | Confirmation test | Peak cortisol (nmol/L) | Other pituitary hormone deficiency | Follow-up | Clinical event |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | V | 45 | PRL-oma | 278 | 313 | If necessary | ITT | 477 | None | No complaints when not using HC. 3 borderline low CRH-tests. Adequate response to ITT. | N |
| 2 | M | 45 | GhA | 373 | 378 | Y | ITT | 569 | None | Adequate response to CRH test during follow-up. ITT thereafter adequate. | N |
| 3 | V | 30 | PRL-oma | 269 | 384 | If necessary | CRH | 516 | None | Did not use HC after CRH test. BC directly postoperative and at 3 months high intermediate. CRH test at 3 months sufficient. | N |
| 4 | V | 42 | Gh/PRL-oma | 220 | 385 | If necessary | ITT | 438 | Primary hypothyroidism | ITT 3 months postoperative adequate. | N |
| 5 | V | 17 | PRL-oma | 424 | 391 | If necessary | ITT | 677 | None | Felt good without HC, ITT 1 month postoperative adequate. | N |
| 6 | M | 57 | PRL-oma | 342 | 427 | If necessary | ITT | 474 | None | Borderline low CRH test. Did not use HC. Received radiotherapy 2 months postoperative. ITT 4 months postoperative showed adequate rise. | N |
| 7 | M | 71 | NFA | 88 | 236 | Y | CRH | 446 | None | Preoperative panhypopituitarism. During follow-up restoration of all hormonal axes. Adequate CRH test 5 months postoperative. | N |
| 8 | V | 55 | NFA | 86 | 360 | Y | ITT | 573 | GHD | Complaints of HC. Two insufficient CRH-tests, but felt better without HC. ITT 6 months postoperative sufficient. | N |
| 9 | M | 47 | NFA | 193 | 362 | Y | ITT | 441 | None | Forgot HC regularly without complaints. ITT 6 months postoperative sufficient. | N |
| 10 | V | 23 | PRL-oma | 172 | missing | If necessary | CRH | 489 | None | Felt good when not using HC. Two high intermediate random cortisol. CRH test 4 months postoperative sufficient. | N |
| 11 | V | 33 | PRL-oma | 160 | 434 | Y | ITT | 522 | None | Borderline adequate CRH test. Persistent complaints of fatigue, started taking HC. ITT 7 months postoperative adequate. | N |
| 12 | V | 44 | NFA | 155 | 435 | N | ITT | 430 | GHD, TSH | Borderline normal CRH test. No HC. 2 months postoperative ER presentation with hypotension. Start HC. ITT 4 months postoperative showed adequate rise. | N |
| 13 | V | 61 | NFA | 199 | 437 | N | CRH | 441 | TSH | Borderline adequate CRH test. CRH test 2 months later adequate. | N |
| 14 | V | 43 | NFA | 212 | 441 | N | ITT | 514 | None | Adequate CRH test. ITT 4 months postoperative showed sufficient response. | N |
| 15 | M | 42 | NFA | 178 | 527 | N | ITT | 580 | None | Adequate CRH test. ITT 6 months postoperative showed sufficient response. | N |
| 16 | V | 33 | NFA | 147 | 753 | N | ITT | 599 | None | Adequate CRH test. ITT 31 months postoperative showed sufficient response. | N |
BC basal cortisol, CRH corticotropic releasing hormone-test, HC hydrocortisone, ITT insulin tolerance test, PRL-oma prolactinoma, GhA somatotroph adenoma, NFA nonfunctioning adenoma, GH/PRL growth hormone/prolactin co-secreting adenoma