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. 2020 Jan 17;11:336. doi: 10.1038/s41467-019-13654-9

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 8 — a–d Open-field test. Total distance travelled a, moving speed b, total time spent in the centre of the field c, and total number of rearings d are shown. e Rotarod test. Latency to fall is shown. Statistical analysis in a–d; two-tailed one-way ANOVA: Total distance, F (2, 19) = 0.6885, P = 0.51441; moving speed, F (2, 19) = 1.19321, P = 0.32476; total number of rearings, F (2, 19) = 0.40367, P = 0.67345; total centre time, F (2, 19) = 3.79839, P = 0.04095, Tukey’s multiple comparison test, A36 vs. non-injected, P = 0.033782; A36 vs. M4, P = 0.612174; M4 vs. non-injected, P = 0.223909. Statistical analysis in e; two-tailed two-way ANOVA: interaction, F (8, 76) = 2.890, P = 0.0072677; gene, F (2, 19) = 6.208, P = 0.00842; time, F (2.771, 52.66), P < 0.00001, Tukey’ multiple comparison test, Day 5, A36 vs. M4, P = 0.0053325; A36 vs. non-injected, P = 0.0247076; M4 vs. non-injected, P = 0.9933278, M4, Day 1 vs. Day 5, P = 0.002306; A36, Day 1 vs. Day 5, P = 0.0885538; non-injected, Day 1 vs. Day 5, P = 0.007349. Error bars represent standard error of the mean. Source data are provided as a Source Data file.