Fig. 3.

A single, prophylactic administration of RS-67,333 prevents novelty-induced hypophagia, but does not alter fear or depressive-like behavior, in female 129S6/SvEv mice. a Experimental design. b All mice exhibited comparable levels of freezing during CFC training. c, d All groups exhibited comparable levels of freezing during re-exposure. e All groups of mice had comparable amounts of immobility during day 1 of the FST. f, g All groups of mice had comparable amounts of immobility during day 2 of the FST. h, i RS-67,333 did not alter distance traveled or time spent in the center of the OF. j Time spent in the open arms of the EPM was comparable between all groups of mice. k Entries into the open arms of the EPM were comparable between all groups of mice. l, m A single, prophylactic dose of RS-67,333 (10 mg/kg) significantly reduced latency to feed in the NSF. n A single, prophylactic dose of RS-67,333 (10 mg/kg) did not alter the amount of food eaten in the home cage or (o) body weight loss. (n = 6–11 female mice per group). Error bars represent ± SEM. *p < 0.05; ***p < 0.001. Sal saline, CFC contextual fear conditioning, FST forced swim test, OF open field, EPM elevated plus maze, NSF novelty suppressed feeding, min minutes, sec seconds, cm centimeters, no number, g grams, mg milligram, kg kilogram