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. 2020 Jan 17;3:6. doi: 10.1038/s41746-019-0214-x

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — The protocol for studies 2, 3, and 4 each included multiple administrations of part III of the MDS-UPDRS. We pooled scores from live raters and video raters across all participants, all sessions, and all three studies of people with PD (N = 754 scores) and fit a mixed effects model with relevant demographic, clinical, and experimental variables. When applying this model to the total score (excluding rigidity items), significant main effects of rating context (whether the rating had been performed live or by video) were observed where the video ratings underestimated the score. Post hoc least squares means estimates of the total MDS-UPDRS part III score from video raters was significantly lower than that from live raters by 4.64 ± 0.64 points (left plot, t = 7.3, p < 0.0001) averaged across session condition and gender. The right three plots show the result of fitting subscale scores for tremor, bradykinesia, and PIGD for the same data set (N = 754) using the same mixed model. Post hoc least squares means estimates of the bradykinesia and tremor subscales from video raters were significantly lower than those of live raters (by 3.35 ± 0.45 points, t = 7.5, p < 0.0001, and 2.18 ± 0.23 points (t = 7.5, p < 0.0001, respectively). Post hoc least squares means estimates for PIGD from video raters, however, were not significantly different than those from live raters (−0.0878 ± 0.13 points, t = −0.675, p = 0.5002).