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. 2020 Jan 17;10:593. doi: 10.1038/s41598-020-57468-y

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fecal bacterial profiles of IBS patients and healthy subjects. Fecal bacterial composition of IBS patients (n = 16, dark grey squares) and healthy subjects (n = 19, light grey circles). (a) Principal component analysis (PCA) of IBS and healthy. (b) Beta-diversity analysis of IBS and healthy. (c) OPLS-DA showing the separation between IBS and healthy, respectively, and the fecal bacterial composition. Multivariate analysis was performed with fecal bacteria as X-variables and IBS and healthy, respectively, as Y-variables. (d) OPLS-DA loading column plot of the fecal bacteria that contributed the most to the separation between IBS and healthy. (e) Score scatter plot from the OPLS-DA showing the separation between the diarrhea predominant (IBS-D, n = 6; yellow large circle), constipation predominant (IBS-C, n = 2, green small circle) and the nonCnonD-IBS (n = 8, dark red square) subtypes, respectively, and the fecal bacterial composition. Multivariate analysis was performed with fecal bacteria as X-variables and IBS subtypes, respectively, as Y-variables. (f) OPLS-DA loading scatter plot of the fecal bacteria that contributed the most to the separation between IBS subtypes. (g) Score scatter plot from the OPLS-DA showing the separation between IBS patients with anxiety (n = 6; dark green squares), and without anxiety (n = 10, light green circles), respectively, and the fecal bacterial composition. Multivariate analysis was performed with fecal bacteria as X-variables and IBS patients with and without anxiety, respectively, as Y-variables. (h) OPLS-DA loading scatter plot of the fecal bacteria that contributed the most to the separation between IBS patients with and without anxiety. * = Significant difference between groups according to the Kruskal-Wallis test or the Mann-Whitney test. U. = Unclassified.