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. 2020 Jan 17;10:627. doi: 10.1038/s41598-020-57431-x

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Signs of remodeling but not of significant ECM degradation were detected in undamaged DDH-OA samples. (A) Panel showing an undamaged DDH-OA sample with MMS 2.5 stained for Aggrecan (i, red), Collagen II (ii, green), overlay (iii), overlay with DAPI (iv), HtrA1 (v, red), HtrA1 + DAPI (vi), MMP13 (vii, red), MMP13 + DAPI (viii), Caspase-3 active (ix, red), Caspase-3 active + DAPI (x) with inset for cells in higher magnification, No primary control (xi, red), and No primary control + DAPI (xii). Only Aggrecan and Collagen II were co-stained on the same sample. The images for the other antibodies’ staining are in equivalent areas. (B) Same array of panels for a damaged DDH-OA sample with MMS 4.5. Scale bars are 200 µm. Images were taken with 20x objective.