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. 2020 Jan 17;10:572. doi: 10.1038/s41598-019-57348-0

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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(A) Score plot for PCoA model with PC1 plotted against PC2 with 95% confidence ellipses around the experimental groups (KO DSS-, KO DSS+, WT DSS- and WT DSS+). (B) Metabolic pathway analysis. The metabolic pathways are represented as circles according to their p values from enrichment analysis (Y-axis) and pathway impact values (X-axis) using MetaboAnalyst 4.0. Darker circle colors indicate more significant changes of metabolites in the corresponding pathway (p values). The size of the circle corresponds to the pathway impact score and is correlated with the centrality of the involved metabolites. (C) Boxplots of the abundances of important bile acids significantly differed among the groups. The center line of each box represents the median, and the top and bottom of the box represent the 75^th and 25^th percentiles of the data, respectively. The top and bottom of the error bars represent the 95^th and 5^th percentiles of the data, respectively. n = 8 mice per group.