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. 2020 Jan 17;10:572. doi: 10.1038/s41598-019-57348-0

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Pearson correlation of microbial community and host gene expression in the colon from WT and MCJ-deficient mice, treated or not with DSS. Pearson correlation analysis indicated that the variation in bacterial community composition and gene expression from the colon wall interaction had significant correlations (P = 0.001). The size and intensity of color for each circle represents the strength of the correlation (the larger, darker circles demonstrate a strong correlation), blue colors illustrate positive correlations and red colors illustrate negative correlation coefficient.