Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Jan 17;11:352. doi: 10.1038/s41467-019-13977-7

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 6 — Model predictions for releases of Ae. aegypti mosquitoes homozygous for the tGD and full-drive systems, parameterized with ballpark estimates: (i) a cleavage frequency of 100% in females and males, (ii) an allelic conversion efficiency, given cleavage, of 50–100% in females and males, and (iii) no fitness costs associated with the Cas9 or gRNA alleles. All resistant alleles are assumed to be in-frame/cost-free. Five weekly releases are simulated, consisting of 100 adult males homozygous for each system, into a population having an equilibrium size of 10,000 adults. Model predictions were computed using 50 realizations of the stochastic implementation of the MGDrivE simulation framework. a Stacked allele counts over time for the full-drive and tGD systems for allelic conversion efficiencies of 100, 90, and 50%. b Allelic conversion efficiency plotted against time to steady state for the full-drive (turquoise) and tGD (yellow) systems. c Fraction of the population carrying at least one transgene over time for the full-drive (turquoise) and tGD (yellow) systems for allelic conversion efficiencies of 100, 90, and 50%. d Allelic conversion efficiency plotted against the fraction of the population carrying at least one transgene at equilibrium for the full-drive (turquoise) and tGD (yellow) systems.