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. 2020 Jan 17;10:608. doi: 10.1038/s41598-020-57484-y

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Enhanced training protocol rescued BID-induced impairment of LTEE. (A) BID blocked the S protocol-induced LTEE in isolated SNs. (A1) Action potentials were recorded from cultured SNs before (pre), and 24 h after treatment with S or vehicle (post). (A2) Summary data (24 h post-test). A value of 100% represented no change in cell excitability. A significant increase in cell excitability was found in the S group, but this LTEE was blocked by BID (Veh, n = 5; BID, n = 5; S, n = 6; BID + S, n = 5 independent experiments). (B) BID-blocked LTEE was restored by the E protocol. (B1) Electrophysiological recording of action potentials (APs). (B2) Summary data. The E protocol rescued BID-impaired LTEE (S, n = 8; BID + S, n = 8; E, n = 6; BID+E, n = 6 independent experiments).