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. 2020 Jan 17;10:608. doi: 10.1038/s41598-020-57484-y

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Schematic model describing activation of Aplysia CREB1, deactivation of Aplysia CREB2, and consequent induction of genes regulated by a cAMP response element (CRE) that is required for the induction of LTF. CREB1 can be phosphorylated by both PKA and RSK. Phosphorylation of CREB1 is assumed necessary for induction of gene expression. CREB2 represses gene expression. Phosphorylation of CREB2 by ERK removes this repression. Arrows and circles indicate positive and negative regulation of transcription, respectively.