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. 2020 Jan 17;11:348. doi: 10.1038/s41467-019-14190-2

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — a Comparison of the TRIM25 mRNA level between HCC and normal tissues in TCGA database. Normal tissues/ Primary tumor tissues: n = 50/371, maximum = 6.396/20.772, upper quartile = 3.461/10.888, median = 2.299/7.382, lower quartile = 1.608/4.781, minimum = 0.925/0.936. Statistical significance was assessed using two-tailed Student’s t-test. b, c Representative images (b) of IHC staining and the relative IHC scores (c) of TRIM25 in HCC tissues and adjacent normal tissues. Scale bar, 50 μm. Data represent the mean ± SEM (adjacent normal tissues, n = 45; HCC tissues, n = 45). The IHC score ranging from 0 to 8 was calculated by multiplying the staining extent score with the staining intensity score. Statistical significance was assessed using two-tailed Student’s t-tests. d, e Representative images of IHC (d) and Kaplan–Meier analysis of overall survival probability (e) of TRIM25 levels in HCC patients. Scale bar, 50 μm. The statistical significance was assessed using two-sided log-rank test according to HCC patients with low or high expression of TRIM25(TRIM25 low expression patients, n = 45; TRIM25 high expression patients, n = 45). f, g The overall survival (f) and disease-free survival probability (g) were compared between TRIM25 High (n = 146) and Low expression (n = 218) in HCC patients from TCGA cohort. h, i Disease/progression-free survival (h) and overall survival (i) were compared between HCC with TRIM25 amplification (n = 11) and without TRIM25 amplification (n = 594) in HCC patients from cBioPortal database. For e, f, g, h and i, the statistical significance was assessed using two-sided log-rank test, log-rank p values were shown.