Fig. 5.

Two doses of ceftriaxone that attenuate alcohol and cocaine-seeking when each drug is consumed alone do not attenuate cue- or cocaine-primed reinstatement of cocaine-seeking in rats with a history of both cocaine and alcohol use. a Cocaine intake (mg/kg) does not differ between groups later assigned to receive vehicle or ceftriaxone. b Alcohol (g/kg) consumed during self-administration did not differ between groups later assigned to receive ceftriaxone or vehicle. Lever presses on the previously active lever during self-administration (c) and extinction training (d) did not differ between groups later assigned to receive ceftriaxone or vehicle during self-administration or extinction training. All groups reinstated pressing on the previously active (e) but not inactive (f) lever during both cue-prime and cocaine-prime reinstatement tests. * = p < 0.05 comparing extinction to test