Fig. 2.

Systemic administration of exendin-4 attenuates oxycodone and cue priming-induced reinstatement of drug-seeking behavior. Rats were pretreated with systemic infusions of vehicle or exendin-4 prior to oxycodone and cue-primed reinstatement test sessions. Food intake, water consumption, and body weight were measured up to 24 h post infusion and reinstatement test sessions (a). Total active lever responses (b) and total infusions (c) were attenuated in rats (n = 12/treatment) pretreated with 3.0 µg/kg exendin-4 versus vehicle (*p < 0.05, Bonferroni). Cumulative chow intake (d), water intake (e), and body weight (f) were not altered in a subset of oxycodone-experienced rats (n = 6/treatment) pretreated with systemic exendin-4 during withdrawal