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. 2020 Jan 17;11:357. doi: 10.1038/s41467-019-14199-7

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — a Accumulation of OxgeMCC-r SAE at the tumor site through the EPR effect. b In vitro T₁-weighted magnetic resonance images of OxgeMCC-r SAE in aqueous solution with various Mn concentrations (mM). c Transverse relativity (r₁) value of 5.44 mM⁻¹ s⁻¹ for OxgeMCC-r SAE. Inset is magnetic resonance phantom images of OxgeMCC-r SAE. Data are presented as mean ± s.e.m. (n = 3). d T₁-weighted MR imaging of 4T1 cells treated with PBS, OxgeMCC-r SAE for 2 h, and OxgeMCC-r SAE for 6 h. e Corresponding relative MR imaging intensity of (d). Data are presented as mean ± s.e.m. (n = 3). f In vivo T₁-weighted magnetic resonance images of 4T1 tumor-bearing mouse at various time points post-injection. Tumor regions are marked with white dashed lines. g Quantitative T₁-weighted MR imaging signals within the tumor site. Data are presented as mean ± s.e.m. (n = 3). h Micrographs of major organs stained with H&E. Scale bar is 50 µm.