Fig. 1.

Parameters are reliable and provide complementary information. (A) Reliability (Pearson’s r) in a group of 19 subjects (ranging in age from 8 to 12 years; see Methods) over repeated scanning sessions, separated by 2 to 8 weeks. Median reliability across all tracts (white bars) was greater than r = 0.75 for all three parameters. Example maps are shown for one representative subject, with linear grayscale values ranging from 0 to 1 for each parameter. (B) Scatter plots show tract average axonal water fraction (AWF), intra-cellular volume fraction (ICVF), and orientation dispersion indices (ODI) for all subjects and two example tracts, estimated in Session 1 vs. Session 2. The identity line is shown in red; the line of best fit is shown in black for each plot. (C) Correlations between parameters from DTI, WMTI, and NODDI for the full sample (n = 53) in two example tracts. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article).