Fig. 6.

The right inferior frontal cortex (IFC) response to emotional faces is modulated by OXTR methylation in adults. Using fMRI, we find a positive association between OXTR methylation and adult neural response to angry faces present in the right IFC (Z = 3.33, p <  0.001; cluster extent (k) = 38, x,y,z = 50, 32, −2) as indexed through the blood oxygenation level dependent signal (BOLD), thus corroborating infant findings and suggesting persistence into adulthood. Relationships between OXTR methylation and neural response to fearful targets were not significant but showed a positive trend. Shaded regions represent the upper and lower 95% confidence intervals. The color bar represents a Z statistical map.