Fig. 3.

Classification of exposure to five human-infective Plasmodium species using a panel of recombinant Plasmodium proteins. a Receiver operating characteristic (ROC) curves of the performance of logistic regression models using all non-cross-reactive antigens for each species. Immunoreactivity data were randomly halved into training and testing sets, to fit the model and calculate ROC curves respectively; this process was repeated ten times to estimate a 95% confidence interval (grey shading). The threshold giving the maximum Youden’s index performance is marked with a dot. b Diagnostic scores from each species’ classifier for each patient and control sample. The classifications of 100 models from randomly split training and testing data were averaged. Brighter yellow indicates higher confidence in a positive diagnosis, according to the scale indicated. Diagnosis type is indicated as P: PCR; M: microscopy