Fig. 4.

Accurate serological diagnosis of Plasmodium knowlesi infections using a small panel of recombinant antigens. a ROC curve for a logistic regression model combining signal from three P. knowlesi antigens. The shaded 95% confidence interval is estimated from ten random sub-samplings of the data into model training and testing sets. The threshold giving the maximum Youden’s index performance is marked with a dot. b Average model confidence in P. knowlesi exposure for each patient (colour-coded along the x-axis: grey: uninfected controls, burgundy: P. knowlesi-infected diagnosed patient) after 100 rounds of sub-sampling into testing sets