Table 3.

Clinical characteristics and brain MRI findings of patients with DOL

Number	Age/ Sex	Toxic agent	Clinical presentation in relapse phase	Time to relapse after initial intoxication	Initial imaging	Delayed phase brain MRI findings	DWI and ADC
9	47 yr, M	Methadone	Disorientation, seizure like activity	9 days	No	Confluent bilateral symmetrical cerebral white matter T2 and FLAIR hyperintensity with sparing of sub cortical U-fibers	No restriction
10	49 yr, M	Methadone	Confusion	18 days	No	Confluent bilateral symmetrical cerebral white matter T2 and FLAIR hyperintensity with sparing of sub cortical U-fibers	No restriction