Table 5.

Summary of published works on DOL

Author(s) year	Age/ Sex	Toxic agent	Time to relapse after initial intoxication	Clinical presentation in relapse phase	First imaging findings	Delayed phase MRI findings	DWI and ADC sequences findings	Prognosis
Ljungar B. et al. 2014 [17]	34 yr, M	Methadone	33 days	Physical, psychological and cognitive deterioration	Cerebral white matter T2 hyperintensity	Cystic changes in bilateral cerebral white matter	Hyperintensity in DWI without ADC confirmation	Recovery
Mittal M. et al. 2010 [6]	38 yr, M	Methadone, benzodiazepine	3 weeks	Physical, psychological and behavioral manifestations	No imaging	Cerebral white matter T2 hyperintensity	No restriction	Partial recovery
Arciniegas 2004 [16]	24 yr, M	Methadone, diazepam	Not mentioned	Apathy, disorientation	No imaging	Cerebral white matter and corpus callosum T2 hyperintensity	Not mentioned	Partial recovery
Torralba A- Moron 2016 [8]	42 yr, M	Methadone, alcohol, benzodiazepine	13 days	Myoclonus, fluctuated consciousness,	Normal CT scan	Cerebral white matter and globous pallidus T2 hyperintensity	Not mentioned	Lack of attention and dysexecutive and amnestic abnormalities persisted
	43 yr, M	Methadone	Not mentioned	low level of consciousness and a bradypnoea	Not mentioned	Cerebral white matter and globous pallidus T2 hyperintensity	Not mentioned	death
Zanin A. 2010 [19]	30mo, F	Methadone	19 days	Agitation, slurred speech, abnormal movement	Normal	Tempromesial, Substantia Nigra and basal ganglia	No restriction	Recovery after 2 month
Andrew Meyer M. 2013 [20]	43 yr, F	Methadone, diazepam	3 weeks	Forgetful& confused, social withdrawal, lack of hygiene	No imaging	Cerebral white matter T2 hyperintensity	Hyperintensity in DWI without ADC confirmation	Recovery
Carroll I. 2012 [9]	43 yr, F	Alprazolam, methadone	33 days	Apathy, inappropriate behavior	No imaging	Cerebral white matter and corpus callosum T2 hyperintensity	Corpus Collosum hyperintensity in DWI without ADC confirmation	Full recovery after 6 month
Shprecher D. 2008 [18]	39 yr, F	Methadone, cocaine	4 weeks	disorientation	No imaging	Cerebral white matter T2 hyperintensity	Hyperintensity in DWI without ADC confirmation	Partial recovery
	58 yr, F	methadone	21 days	Paranoid and inappropriate behavioral	No imaging	Cerebral white matter T2 hyperintensity	Not mentioned	Partial recovery
	56 yr, F	Methadone, fentanyl, benzodiazepine	15 days	Cognitive deterioration	Not mentioned	Cerebral white matter T2 hyperintensity	Hyperintensity in DWI without ADC confirmation	Partial recovery