Table 1.
27-Gene immune signature
| Gene | Name | Frequency in resampling | Average P-value | Coefficient |
|---|---|---|---|---|
| RFXAP | Regulatory factor X-associated protein | 957 | 0.013 | 0.073 |
| ULBP1 | UL16 binding protein 1 | 927 | 0.016 | 0.007 |
| TMSB4Y | Thymosin beta 4 | 1000 | 0.002 | − 0.117 |
| RBP4 | Retinol binding protein 4 | 923 | 0.018 | 0.067 |
| LCNL1 | Lipocalin-like 1 | 1000 | 0.002 | − 0.056 |
| CCR6 | Chemokine (C-C motif) receptor 6 | 976 | 0.008 | − 0.009 |
| KLRK1 | Killer cell lectin-like receptor subfamily K | 1000 | 0.000 | − 0.093 |
| PTX3 | Pentraxin-related gene | 999 | 0.002 | 0.037 |
| MASP1 | Mannan-binding lectin serine peptidase 1 | 1000 | 7.447 | − 0.203 |
| HRG | Histidine-rich glycoprotein | 938 | 0.016 | 0.043 |
| CCL22 | Chemokine (C-C motif) ligand 22 | 992 | 0.005 | − 0.061 |
| OLR1 | Oxidized low density lipoprotein (lectin-like) receptor 1 | 996 | 0.005 | 0.040 |
| ROBO1 | Roundabout | 923 | 0.017 | − 0.026 |
| BTC | Betacellulin | 902 | 0.020 | 0.146 |
| CHGB | Chromogranin B | 1000 | 0.001 | 0.113 |
| DKK1 | Dickkopf homolog 1 | 1000 | 9.203 | 0.088 |
| HBEGF | Heparin-binding EGF-like growth factor | 905 | 0.022 | 0.109 |
| INHBB | Inhibin beta B | 946 | 0.015 | 0.009 |
| PDGFA | Platelet-derived growth factor alpha polypeptide | 1000 | 0.001 | 0.037 |
| AVPR2 | Arginine vasopressin receptor 2 | 999 | 0.002 | − 0.043 |
| IL20RA | interleukin 20 receptor | 952 | 0.012 | − 0.067 |
| RORB | RAR-related orphan receptor B | 947 | 0.015 | − 0.010 |
| TNFRSF18 | Tumor necrosis factor receptor superfamily member 18 | 934 | 0.017 | − 0.071 |
| TNFRSF25 | Tumor necrosis factor receptor superfamily member 25 | 987 | 0.006 | − 0.051 |
| TNFRSF4 | Tumor necrosis factor receptor superfamily member 4 | 1000 | 0.002 | − 0.054 |
| SH3BP2 | SH3-domain binding protein 2 | 999 | 0.002 | − 0.004 |
| ICOS | Inducible T-cell co-stimulator | 984 | 0.008 | − 0.017 |