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Model of Ect2 regulation. CS, the centralspindlin complex; PF, positive feedback; PM, plasma membrane; RhoA (T), GTP-bound RhoA; double arrow, centralspindlin–Ect2 interaction. Ect2 is autoinhibited in the ground state. The activator RhoA (GTP-bound, yellow) binds to the PH domain, allosterically releasing the Ect2 inhibition, and the substrate RhoA (cyan) binds to the catalytic center, ready for GTP–GDP exchange (EX).
