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. 2019 Dec 27;117(2):836–847. doi: 10.1073/pnas.1912500117

Fig. 7.

Fig. 7.

Probing the regulatory logic of bursting and the transcriptional time window. (A and B) Fraction of nuclei in the transcriptionally quiescent state (A) and fraction of nuclei in the bursting ON state (B) as a function of time and position along the embryo. (C) Snapshots of input transcription factor levels and predicted eve mRNA levels of our “average” embryo at 10, 25, and 40 min into nuclear cycle 14. (D) Predicted fraction of quiescent nuclei for progressively more complex regression models. The simplest model with the highest likelihood is highlighted in purple. The color-coded circles indicate which of the 4 transcription factors—Krüppel (Kr), Giant (Gt), Hunchback (Hb), and Bicoid (Bcd)—were included in each version of the model. (E) Model likelihood indicating that Krüppel and Giant levels are sufficient to recapitulate the fraction of quiescent nuclei in D. (F) Predicted fraction of nuclei in the ON state. The simplest and most likely model is highlighted in purple. (G) Model scores reveal that Giant, Krüppel, and Hunchback recapitulate the bursting behavior in F.