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Cumulative risk of cancer in leukemia, pancreas, and colon. Simulations are stopped at 75 y of age. Number of simulations: 10,000 individuals per tissue. The true curves are obtained from ref. 23. “Colon,” sporadic colorectal tumors; “Leukemia,” leukemias (all); “Lynch,” CRCs in patients with Lynch syndrome; “Pancreas,” pancreatic ductal adenocarcinoma.
