Table 2.
Association between nucleotide excision repair polymorphisms and colorectal cancer risk in the validation stage1, n (%)
| SNP genotype | NCBI Ref | CRC | CON | P value | OR (95%CI) |
| DDB2 | |||||
| rs2029298 | n = 849 | n = 849 | |||
| GG | 32 (37.2) | 393 (46.3) | 385 (45.3) | 1 (Ref) | |
| GA | 38 (44.2) | 359 (42.3) | 368 (43.3) | 0.650 | 0.95 (0.78-1.17) |
| AA | 16 (18.6) | 97 (11.4) | 96 (11.3) | 0.919 | 0.98 (0.72-1.35) |
| GA + AA vs GG | 0.677 | 0.96 (0.79-1.16) | |||
| AA vs GA + GG | 0.980 | 1.00 (0.74-1.36) | |||
| PHWE | 0.584 | 0.570 | |||
| ERCC1 | |||||
| rs11615 | n = 850 | n = 847 | |||
| CC | 54 (62.8) | 518 (60.9) | 494 (58.3) | 1 (Ref) | |
| CT | 24 (27.9) | 293 (34.5) | 305 (36.0) | 0.355 | 0.91 (0.74-1.11) |
| TT | 8 (9.3) | 39 (4.6) | 48 (5.7) | 0.248 | 0.77 (0.50-1.20) |
| CT + TT vs CC | 0.244 | 0.89 (0.73-1.08) | |||
| TT vs CT + CC | 0.321 | 0.80 (0.52-1.24) | |||
| PHWE | 0.200 | 0.919 | |||
| rs735482 | n = 836 | n = 838 | |||
| CC | 18 (20.9) | 169 (20.2) | 168 (20.0) | 1 (Ref) | |
| CA | 40 (46.5) | 405 (48.4) | 403 (48.1) | 0.966 | 1.00 (0.77-1.28) |
| AA | 28 (32.6) | 262 (31.3) | 267 (31.9) | 0.856 | 0.98 (0.74-1.28) |
| CA + AA vs CC | 0.920 | 0.99 (0.78-1.26) | |||
| AA vs CA + CC | 0.812 | 0.98 (0.79-1.20) | |||
| PHWE | 0.752 | 0.477 | |||
| ERCC2 | |||||
| rs1052555 | n = 852 | n = 851 | |||
| CC | NA | 767 (90.0) | 759 (89.2) | 1 (Ref) | |
| CT | NA | 84 (9.9) | 91 (10.7) | 0.605 | 0.92 (0.67-1.26) |
| TT | NA | 1 (0.1) | 1 (0.1) | 0.970 | 0.95 (0.06-15.21) |
| CT + TT vs CC | 0.602 | 0.92 (0.67-1.26) | |||
| TT vs CT + CC | 0.971 | 0.95 (0.06-15.22) | |||
| PHWE | NA | 0.307 | |||
| rs50871 | n = 838 | n = 845 | |||
| TT | 40 (46.5) | 429 (51.2) | 451 (53.4) | 1 (Ref) | |
| TG | 36 (41.9) | 337 (40.2) | 358 (42.4) | 0.922 | 0.99 (0.81-1.21) |
| GG | 10 (11.6) | 72 (8.6) | 36 (4.3) | 0.001 | 2.09 (1.37-3.19) |
| TG + GG vs TT | 0.374 | 1.09 (0.90-1.32) | |||
| GG vs TG + TT | < 0.001 | 2.08 (1.38-3.15) | |||
| PHWE | 1.000 | 0.001 | |||
| ERCC5 | |||||
| rs1047768 | n = 839 | n = 845 | |||
| CC | 8 (9.3) | 75 (8.9) | 71 (8.4) | 1 (Ref) | |
| CT | 30 (34.9) | 348 (41.5) | 351 (41.5) | 0.735 | 0.94 (0.66-1.35) |
| TT | 48 (55.8) | 416 (49.6) | 423 (50.1) | 0.708 | 0.94 (0.66-1.33) |
| CT + TT vs CC | 0.717 | 0.94 (0.67-1.32) | |||
| TT vs CT + CC | 0.822 | 0.98 (0.81-1.19) | |||
| PHWE | 0.480 | 0.880 | |||
| rs2094258 | n = 843 | n = 841 | |||
| GG | 38 (44.2) | 307 (36.4) | 326 (38.8) | 1 (Ref) | |
| GA | 42 (48.8) | 409 (48.5) | 392 (46.6) | 0.389 | 1.10 (0.89-1.35) |
| AA | 6 (7.0) | 127 (15.1) | 123 (14.6) | 0.615 | 1.08 (0.80-1.45) |
| GA + AA vs GG | 0.370 | 1.10 (0.90-1.33) | |||
| AA vs GA + GG | 0.837 | 1.03 (0.79-1.35) | |||
| PHWE | 0.403 | 0.770 | |||
| rs2228959 | n = 841 | n = 851 | |||
| CC | 74 (86.0) | 754 (89.7) | 782 (91.9) | 1 (Ref) | |
| CA | 12 (14.0) | 83 (9.9) | 62 (7.3) | 0.051 | 1.41 (1.00-1.99) |
| AA | 0 (0.0) | 4 (0.5) | 7 (0.8) | 0.408 | 0.59 (0.17-2.04) |
| CA + AA vs CC | 0.095 | 1.33 (0.95-1.85) | |||
| AA vs CA + CC | 0.383 | 0.58 (0.17-1.98) | |||
| PHWE | 1.000 | < 0.001 | |||
| rs2296147 | n = 844 | n = 847 | |||
| TT | 52 (60.5) | 508 (60.2) | 517 (61.0) | 1 (Ref) | |
| TC | 32 (37.2) | 294 (34.8) | 289 (34.1) | 0.684 | 1.04 (0.85-1.28) |
| CC | 2 (2.3) | 42 (5.0) | 41 (4.8) | 0.904 | 1.03 (0.66-1.61) |
| TC + CC vs TT | 0.679 | 1.04 (0.86-1.27) | |||
| CC vs TC + TT | 0.952 | 1.01 (0.65-1.58) | |||
| PHWE | 0.439 | 0.940 | |||
| rs873601 | n = 842 | n = 837 | |||
| GG | 16 (18.6) | 230 (27.3) | 223 (26.6) | 1 (Ref) | |
| GA | 48 (55.8) | 435 (51.7) | 413 (49.3) | 0.807 | 1.03 (0.82-1.29) |
| AA | 22 (25.6) | 177 (21.0) | 201 (24.0) | 0.310 | 0.87 (0.66-1.14) |
| GA + AA vs GG | 0.849 | 0.98 (0.79-1.22) | |||
| AA vs GA + GG | 0.155 | 0.85 (0.67-1.07) | |||
| PHWE | 0.439 | 0.719 | |||
| XPA | |||||
| rs10817938 | n = 823 | n = 822 | |||
| TT | 58 (67.4) | 511 (62.1) | 547 (66.5) | 1(Ref) | |
| TC | 24 (27.9) | 259 (31.5) | 241 (29.3) | 0.231 | 1.14 (0.92-1.41) |
| CC | 4 (4.7) | 53 (6.4) | 34 (4.1) | 0.021 | 1.70 (1.08-2.66) |
| TC + CC vs TT | 0.071 | 1.21 (0.98-1.48) | |||
| CC vs TC + TT | 0.033 | 1.62 (1.04-2.52) | |||
| PHWE | 0.655 | 0.257 | |||
| rs3176629 | n = 847 | n = 852 | |||
| CC | 68 (79.1) | 689 (81.3) | 706 (82.9) | 1 (Ref) | |
| CT | 18 (20.9) | 151 (17.8) | 133 (15.6) | 0.240 | 1.17 (0.90-1.51) |
| TT | 0 (0.0) | 7 (0.8) | 13 (1.5) | 0.225 | 0.56 (0.22-1.42) |
| CT + TT vs CC | 0.399 | 1.11 (0.87-1.43) | |||
| TT vs CT + CC | 0.205 | 0.55 (0.22-1.39) | |||
| PHWE | 0.752 | 0.024 | |||
| XPC | |||||
| rs2607775 | n = 840 | n = 850 | |||
| CC | 76 (84.5) | 755 (89.9) | 792 (93.2) | 1(Ref) | |
| CG | 12 (13.3) | 80 (9.5) | 56 (6.6) | 0.027 | 1.49 (1.05-2.13) |
| GG | 2 (2.2) | 5 (0.6) | 2 (0.2) | 0.219 | 2.81 (0.54-14.56) |
| CG + GG vs CC | 0.016 | 1.54 (1.09-2.18) | |||
| GG vs CG + CC | 0.238 | 2.69 (0.52-13.95) | |||
| PHWE | 0.251 | 0.343 |
1P was adjusted by gender and age. Statistically significant associations are in bold (P < 0.05). SNP: Single nucleotide polymorphism; NCBI Ref: Reference frequency of the SNPs in healthy controls (Beijing Han, China, NCBI database); CRC: Colorectal cancer; CON: Control; OR: Odds ratio; CI: Confidence interval; PHWE: Hardy-Weinberg Equilibrium in control group; NA: Not available.