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. 2019 Dec 15;11(12):681. doi: 10.3390/pharmaceutics11120681

Table 1.

The 1,4-dihydropyridine (DHP) derivative drugs tested in this work as novel antimicrobials against Helicobacter pylori infection.

Drug (Brand Name) DHP Generation Molecular Formula Chemical Structure Mouse LD50 (mg/kg, oral) *
Nifedipine (Adalat) first C17H18N2O6 graphic file with name pharmaceutics-11-00681-i001.jpg 202
Nicardipine (Cardene) second C26H29N3O6 graphic file with name pharmaceutics-11-00681-i002.jpg 305
Nisoldipine (Sular) second C20H24N2O6 graphic file with name pharmaceutics-11-00681-i003.jpg 411
Nimodipine (Nimotop) second C21H26N2O7 graphic file with name pharmaceutics-11-00681-i004.jpg 940
Nitrendipine (Baypress) third C18H20N2O6 graphic file with name pharmaceutics-11-00681-i005.jpg 2540
Lercanidipine (Zanidip) fourth C36H41N3O6 graphic file with name pharmaceutics-11-00681-i006.jpg 622

* Median lethal dose (LD50) data from PubChem. Lercanidipine LD50 information from [31].