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. 2019 Dec 14;9(12):303. doi: 10.3390/metabo9120303

Table 2.

List of bioinformatics and statistical tools for plant metabolomics workflow.

Tool Weblink Major Function Reference
MetaboAnalyst www.metaboanalyst.ca/ Statistical analysis [103]
MetaboSearch http://omics.georgetown.edu/metabosearch.html Data annotation [104]
MeltDB 2.0 https://meltdb.cebitec.uni-bielefeld.de Data processing [93]
metaP-server http://metabolomics.helmholtz-muenchen.de/metap2/ Data analysis [105]
MetExplore http://metexplore.toulouse.inra.fr Pathway analysis [106]
Metabox https://github.com/kwanjeeraw/metabox Analysis workflow [100]
METLIN https://metlin.scripps.edu/ Metabolite annotation [89]
MetAlign www.metalign.nl Data processing & statistical analysis [95]
MetiTree http://www.metitree.nl/ Data annotation [107]
Metab www.metabolomics.auckland.ac.nz/index.php/downloads Workflow analysis [74]
MetabR http://metabr.r-forge.r-project.org/ R package [79]
MetaboAnalystR https://github.com/xialab/MetaboAnalystR R package [80]
Lilikoi https://github.com/lanagarmire/lilikoi R package [81]
MetaboDiff http://github.com/andreasmock/MetaboDiff/a R package [82]
MetFrag http://c-ruttkies.github.io/MetFrag Metabolite annotation [108]
MetaGeneAlyse http://metagenealyse.mpimp-golm.mpg.de/ Metabolite data analysis [90]
Metacrop 2.0 http://metacrop.ipk-gatersleben.de Data annotation [109]
MetAssign http://mzmatch.sourceforge.net/ Data annotation [110]
MET-COFEA http://bioinfo.noble.org/manuscript-support/met-cofea/ Data processing [111]
MetPA http://metpa.metabolomics.ca Pathway analysis [91]
iMet-Q http://ms.iis.sinica.edu.tw/comics/Software_iMet-Q.html Data processing [94]
Babelomics 5.0 http://www.babelomics.org/ Statistical analysis [101]
XCMS https://xcmsonline.scripps.edu Data processing [85]
MZedDB http://maltese.dbs.aber.ac.uk:8888/hrmet/index.html Data annotation [97]
MassBank http://www.massbank.jp/ Metabolite annotation [112]
MaxQuant https://www.maxquant.org/ Data annotation & processing [113]
MetFusion http://mgerlich.github.io/MetFusion/ Integrated compound detection [114]
MAVEN https://maven.apache.org/ Data processing [115]
MZmine2 http://mzmine.github.io/ Data processing [116]
MSEA http://www.metaboanalyst.ca/ Pathway analysis [92]
MS-Dial http://prime.psc.riken.jp/Metabolomics_Software/MS-DIAL/ Data processing [96]
MarVis http://marvis.gobics.de/ Metabolite annotation [117]
Mummichog http://mummichog.org Pathway analysis [118]
MMCD http://mmcd.nmrfam.wisc.edu/ Metabolite annotation [119]
COVAIN http://www.univie.ac.at/mosys/software.html Statistical analysis [62]
CAMERA https://bioconductor.org/packages/release/bioc/html/CAMERA.html Data annotation [120]
CDK https://cdk.github.io Structural annotation [121]
CFM-ID http://cfmid.wishartlab.com Metabolite identification [122]
ADAP http://www.du-lab.org/software.htm/ Data processing [123]
KEGG http://www.genome.jp/kegg/ Metabolic models [98]
GenePattern http://software.broadinstitute.org/cancer/software/genepattern/ Statistical analysis [102]
Galaxy-M https://github.com/Viant-Metabolomics/Galaxy-M Workflow analysis [99]