. 2020 Jan 7;2020:8736509. doi: 10.1155/2020/8736509

Table 3.

Survival analysis data of the included studies.

Study	Marker	Cut-off	Survival analysis	HR	95% CI	p value	Variables for multivariate analysis
Aggerholm-Pedersen et al. [30]	GPS	—	DSS^a	3.367	1.993-5.688	<0.001	Age, tumor size, histology, margin, soft tissue extension, comorbidity
Aggerholm-Pedersen et al. [30]	GPS	—	OS^a	3.387	2.062-5.564	<0.001
Liu et al. [31]	GPS	—	OS	2.25	1.222-4.145	0.009	Enneking stage, metastasis, tumor site, CRP, NLR, PLR, LMR
Morhij et al. [32]	mGPS	—	CSS	2.03	1.31-3.16	0.002	Tumor size, grade, CRP, ALB, WCC
Morhij et al. [32]	mGPS	—	RFS	1.92	1.31-2.83	0.001	Tumor size, grade, CRP, ALB
Li et al. (1) [34]	GPS	—	OS	1.95	1.33-2.87	0.001	Univariate analysis
Li et al. (1) [34]	CAR	0.210	OS	2.62	1.70-4.03	<0.001	Metastasis, tumor site
Li et al. (2) [33]	GPS	—	OS	2.27	1.28-4.02	0.006	Univariate analysis
Li et al. (2) [33]	CAR	0.225	OS	2.28	1.23-4.26	0.009	Enneking stage, tumor site
Maretty-Kongstad et al. [35]	GPS	—	DSS^a	1.731	1.070-2.801	0.026	Age, tumor size, grade, histology, tumor depth, comorbidity
Liang et al. [36]	Hs-mGPS	—	OS^a	3.162	2.000-4.998	<0.001	Univariate analysis
	Hs-mGPS	—	DFS^a	2.232	1.542-3.231	<0.001	Univariate analysis
	CAR	0.1035	OS	2.47	1.47-4.14	0.001	Grade
	CAR	0.1035	DFS	1.88	1.22-2.91	0.004	Age, grade
Tsuda et al. [37]	Hs-mGPS	—	EFS	1.74	1.01-2.99	0.046	Age, sex, UICC stage, margin, ECOG PS
Jiang et al. [38]	GPS	—	OS	0.941	0.117-7.585	0.954	mGPS, age, pathological grade, primary tumor depth
	GPS	—	PFS	0.312	0.047-2.664	0.353	mGPS, age, pathological grade, primary tumor depth
	mGPS		OS	1.660	0.22-12.534	0.623	GPS, age, pathological grade, primary tumor depth
	mGPS		PFS	9.932	1.357-72.716	0.024	GPS, age, pathological grade, primary tumor depth
Sasaki et al. [39]	GPS	—	OS	2.098	1.229-3.388	0.002	Univariate analysis
Aggerholm-Pedersen et al. [40]	GPS	—	DSS^a	3.195	1.253-8.147	0.015	Age, comorbidity, histology, site of metastasis
Xu et al. [41]	CAR	1.5	OS	1.930	1.040-3.579	0.037	Age, Frankel score, resection mode, D-dimer, PLR
Xu et al. [41]	CAR	1.5	DFS	1.687	0.916-3.106	0.093	Age, Frankel score, metastasis, resection mode, D-dimer, PLR

GPS: Glasgow prognostic score; mGPS: modified GPS; Hs-mGPS: high sensitive modified GPS; CAR: C-reactive protein to albumin ratio; OS: overall survival; DSS: disease-specific survival; DFS: disease-free survival; RFS: recurrence-free survival; EFS: event-free survival; PFS: progression-free survival; HR: hazard ratio; CI: confidence interval; CRP: C-reactive protein; NLR: neutrophil to lymphocyte ratio; PLR: platelet to lymphocyte ratio; LMR: lymphocyte to monocyte ratio; ALB: albumin; WCC: white cell counts; UICC: Union for International Cancer Control; ECOG PS: Eastern Cooperative Oncology Group performance status.^aThese studies reported HRs for GPS 1 and GPS 2 separately. We combined these 2 groups and calculated a combined HR for the overall elevated GPS.