Table 2.
Functions of potential target genes based on KEGG pathway analysis.
| Term | Number of pathway gene | P value |
|---|---|---|
| Pathways in cancer | IGF1, FLT3, FGFR1, MET, PIK3CG, MMP9, NOS2, CDK2, HSP90AA1, PIK3R1, MDM2, RAC2, GSTP1, MMP2, MAPK1, FGFR2, CASP3, PPARG, EGFR, BMP2, AKT1, BRAF, MAPK8 | 1.05E – 10 |
|
| ||
| Proteoglycans in cancer | IGF1, SRC, FGFR1, MET, PIK3CG, MMP9, ESR1, PIK3R1, KDR, PDPK1, MDM2, MMP2, PTPN11, MAPK1, CASP3, PLAU, MAPK14, EGFR, AKT1, BRAF | 2.44E – 13 |
|
| ||
| PI3K-Akt signaling pathway | IGF1, FGFR1, MET, PIK3CG, CDK2, IL2, HSP90AA1, PIK3R1, KDR, PDPK1, MDM2, NOS3, FGFR2, MAPK1, INSR, EGFR, AKT1 | 7.80E – 07 |
|
| ||
| Rap1 signaling pathway | IGF1, SRC, FGFR1, MET, PIK3CG, PIK3R1, KDR, RAC2, FGFR2, MAPK1, INSR, MAPK14, EGFR, AKT1, BRAF, | 5.12E – 08 |
|
| ||
| FoxO signaling pathway | IGF1, PIK3CG, CDK2, PIK3R1, PDPK1, MDM2, SOD2, MAPK1, INSR, MAPK14, EGFR, AKT1, MAPK8, BRAF | 1.74E – 09 |
|
| ||
| Focal adhesion | IGF1, SRC, MET, PIK3CG, PIK3R1, KDR, MYLK, PDPK1, RAC2, MAPK1, EGFR, AKT1, MAPK8, BRAF | 3.09E – 07 |
|
| ||
| Ras signaling pathway | IGF1, PIK3R1, KDR, RAC2, FGFR1, PTPN11, MET, MAPK1, FGFR2, PIK3CG, INSR, EGFR, AKT1, MAPK8 | 8.97E – 07 |
|
| ||
| Prostate cancer | IGF1, FGFR1, PIK3CG, CDK2, PIK3R1, HSP90AA1, PDPK1, MDM2, FGFR2, MAPK1, EGFR, AKT1, BRAF | 1.42E – 10 |
|
| ||
| Insulin resistance | NR1H3, PIK3CG, PYGL, PTPN1, PIK3R1, PDPK1, NOS3, PTPN11, INSR, PPARA, AKT1, NR1H2, MAPK8 | 1.62E – 09 |
|
| ||
| Estrogen signaling pathway | HSP90AA1, PIK3R1, HSPA8, ESR1, SRC, NOS3, MMP2, MAPK1, PIK3CG, MMP9, EGFR, AKT1 | 8.25E – 09 |
|
| ||
| MAPK signaling pathway | MAPT, HSPA8, RAC2, FGFR1, MAPK1, FGFR2, CASP3, MAPK14, EGFR, AKT1, BRAF, MAPK8 | 9.21E – 05 |
|
| ||
| Hepatitis C | PIK3R1, NR1H3, PDPK1, MAPK1, PIK3CG, MAPK14, PPARA, EGFR, AKT1, BRAF, MAPK8 | 1.68E – 06 |
|
| ||
| Regulation of actin cytoskeleton | PIK3R1, MYLK, SRC, RAC2, FGFR1, MAPK1, FGFR2, PIK3CG, EGFR, F2, BRAF | 9.31E – 05 |
|
| ||
| Melanoma | PIK3R1, IGF1, MDM2, FGFR1, MET, MAPK1, PIK3CG, EGFR, AKT1, BRAF | 6.49E – 08 |
|
| ||
| Progesterone-mediated oocyte maturation | HSP90AA1, PIK3R1, IGF1, MAPK1, PIK3CG, MAPK14, CDK2, AKT1, BRAF, MAPK8 | 3.88E – 07 |
|
| ||
| Sphingolipid signaling pathway | PIK3R1, PDPK1, RAC2, ABCC1, NOS3, MAPK1, PIK3CG, MAPK14, AKT1, MAPK8 | 5.91E – 06 |
|
| ||
| Insulin signaling pathway | PIK3R1, PDPK1, MAPK1, PIK3CG, INSR, PYGL, PTPN1, AKT1, BRAF, MAPK8 | 1.85E – 05 |
|
| ||
| VEGF signaling pathway | PIK3R1, KDR, SRC, RAC2, NOS3, MAPK1, PIK3CG, MAPK14, AKT1 | 2.81E – 07 |
|
| ||
| Central carbon metabolism in cancer | PIK3R1, FLT3, FGFR1, MET, MAPK1, FGFR2, PIK3CG, EGFR, AKT1 | 4.11E – 07 |
|
| ||
| HIF-1 signaling pathway | PIK3R1, IGF1, NOS3, MAPK1, PIK3CG, INSR, NOS2, EGFR, AKT1 | 9.27E – 06 |