Figure 1.

Concept of the tubal precursors. Some secretory cells in the fimbria exhibit expanded growth, leading to secretory cell outgrowth (SCOUT), and are likely to undergo genotoxic oxidative stress, probably due to exposure to follicular fluid at the time of ovulation. The DNA damage response will then be induced by activating the p53 pathway, leading to subsequent activation of ATM/ATR signaling and cell cycle arrest. Thus, p53 signature is characterized as negative for Ki‐67 or MIB1 staining. Genotoxic stress or some other factors in p53 signature cells induces or causes p53 gene mutation, leading to the development of serous tubal intraepithelial lesions (STILs) and serous tubal intraepithelial carcinoma (STIC)