Table 3.
Large‐scale retrospective studies for ovarian cancer risk reduction by salpingectomy or related operations
| Madsen et al (Ref. 78/) | Falconer et al (Ref. 79) | |
|---|---|---|
| Design | Retrospective case‐control | Retrospective cohort |
| Setting | Registry in Danish population | Registry in Swedish population |
| Population | 13 241 ovarian cancer cases | 98 026 cases with hysterectomy |
| 194 689 age‐matched population control | 37 348 cases with hysterectomy with BSO | |
| 34 433 cases with salpingectomy | ||
| 81 658 cases with tubal sterilization | ||
| 5 449 119 unexposed cohort | ||
| Comparator | Observation | Unexposed population |
| Outcome | Incidence of ovarian cancer | Incidence of ovarian cancer |
| Impact of hysterectomy | HR 0.79 (95% CI, 0.70‐0.88) | |
| Impact of hysterectomy with BSO | HR 0.06 (95% CI, 0.03‐0.12) | |
| Impact of salpingectomy | OR 0.58 (95% CI, 0.36‐0.95) | HR 0.36 ( 95% CI, 0.52‐0.81) |
| Impact of tubal sterilization | OR 0.87 (95% CI, 0.78‐0.98) | HR 0.69 (95% CI, 0.64‐0.81) |
Abbreviations: BSO, bilateral salpingo‐oophorectomuy; HR, hazard ratio; OR, odds ratio.