Table 5.
The multivariate Cox logistic regression of factors affecting the progression free survival and overall survival in NSCLC patients treated with first line chemotherapy
| Factor | P value | Hazard ratio | 95% CI | |
|---|---|---|---|---|
| Progression free survival | ||||
| No surgical treatment | .0051 | 9.1637 | 1.9449‐43.1752 | |
| Severe hematological complications | .0160 | 2.3047 | 1.1685‐4.5457 | |
| Metastatic disease | .0095 | 2.2547 | 1.2200‐4.1669 | |
| A/G genotype of rs11615 ERCC1 gene | .0404 | 1.9193 | 1.0289‐3.5801 | |
| C/T genotype of rs34300454 TOP2A gene | .0006 | 2.8826 | 1.5792‐5.2617 | |
| Overall model fit: P < .0001, χ 2 = 42 052 | ||||
| Overall survival | ||||
| Lack of second line chemotherapy | <.0001 | 5.9322 | 2.8476‐12.3584 | |
| Occupational exposure on carcinogens | .0207 | 0.4177 | 0.1994‐0.8751 | |
| No surgical treatment | <.0001 | 35.0140 | 7.7403‐158.3883 | |
| Severe hematological complications | .0020 | 3.8917 | 1.6458‐9.2024 | |
| Lack of radiotherapy | .0023 | 2.9246 | 1.4686‐5.8244 | |
| Positive smoking status | .0037 | 0.1580 | 0.0454‐0.5502 | |
| C/T genotype of rs13695 TOP2A | .0457 | 1.6729 | 1.0098‐2.7713 | |
| rs34300454 TOP2A | .0008 | 2.8946 | 1.5598‐5.3713 | |
| Overall model fit: P < .0001, χ 2 = 58 230 | ||||
Abbreviation: NSCLC, non‐small cell lung cancer.