Table 2.
Epidermal growth factor receptor (EGFR) subtypes and their proportions
| EGFR subtypes | The number of mutations | % (EGFRm+) | % (Total number) |
|---|---|---|---|
| Single‐site mutation | |||
| Exon 18 | 6 | 2.7 | 1.1 |
| Non‐frameshift deletion mutation | 2 | 0.9 | 0.4 |
| G719X missense mutation | 4 | 1.8 | 0.7 |
| Exon 19 | 86 | 38.1 | 15.6 |
| Non‐frameshift deletion mutation | 86 | 38.1 | 15.6 |
| Exon 20 | 10 | 4.4 | 1.8 |
| Non‐frameshift insertion mutation | 10 | 4.4 | 1.8 |
| Exon 21 | 79 | 35.0 | 14.3 |
| L858R | 76 | 33.6 | 13.8 |
| L861Q | 3 | 1.3 | 0.5 |
| Double‐site mutation | |||
| 18/20 | 2 | 0.9 | 0.4 |
| G719X/S768I | 1 | 0.4 | 0.2 |
| G719X/A767V | 1 | 0.4 | 0.2 |
| 18/21 | 1 | 0.4 | 0.2 |
| G719X/L861Q | 1 | 0.4 | 0.2 |
| 19/20 | 18 | 8.0 | 3.3 |
| del/T790M | 17 | 7.5 | 3.1 |
| del/R776H | 1 | 0.4 | 0.2 |
| 21/20 | 20 | 8.8 | 3.6 |
| L858R/T790M | 18 | 8.0 | 3.3 |
| L858R/R776H | 1 | 0.4 | 0.2 |
| L858R/A767V | 1 | 0.4 | 0.2 |
| 18/18 | 1 | 0.4 | 0.2 |
| G719X/E709A | 1 | 0.4 | 0.2 |
| 19/19 | 1 | 0.4 | 0.2 |
| del/c.2248G>C | 1 | 0.4 | 0.2 |
| 21/21 | 2 | 0.9 | 0.4 |
| L833V/H835L | 1 | 0.4 | 0.2 |
| L858R/L833V | 1 | 0.4 | 0.2 |
| Total | 226 | 100 | 40.9 |