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. 2020 Jan 17;40(1):BSR20193267. doi: 10.1042/BSR20193267

Figure 6. The role of CXCL12 in AS progression.

Figure 6

AS initiates the infiltration of ox-LDLs into the subendothelial space of arteries, which leads to stimulation of inflammatory infiltration and adhesion between endothelial cells and inflammatory monocytes. Ox-LDLs induced the release of CXCL12 from macrophages and further promoted HA-VSMC proliferation and foam cell formation. Our results demonstrated that CXCL12 expression was significantly increased in the in vitro and in vivo AS models. Moreover, inhibition of CXCL12 reduced progression in the AS cell model.