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. 2019 Dec 24;19:790–803. doi: 10.1016/j.omtn.2019.12.009

Figure 1.

Figure 1

Expression Profiles of Peripheral Plasma Exosomal lncRNA in Human CRCs

(A) Transmission electron microscopy images of plasma exosomes of CRC patients. (B) Western blotting analysis of the exosomal markers Tsg101, CD63, and Alix in plasma exosomes of CRC patients and healthy control. (C) Microarray analysis of lncRNA profile in the NC group (n = 5) and CRC group (n = 5). (D) Expression levels of the most top 10 upregulated lncRNAs in CRC patients and NC individuals were determined by quantitative real-time PCR assay. (E) UCA1 expression in CRC and normal samples from the TCGA colon adenocarcinoma (COAD) dataset. (F) Kaplan-Meier analyses of the correlations between UCA1 expression and overall survival (OS) of COAD patients from the TCGA COAD dataset. (G) Kaplan-Meier analyses of the correlations between UCA1 expression and disease-free survival (DFS) of COAD patients from the TCGA COAD dataset. Log-rank test was used to calculate p values. All tests were performed at least three times. Data were expressed as mean ± SD. *p < 0.05; **p < 0.01; ***p < 0.001.