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. 2020 Jan 9;10:1522. doi: 10.3389/fphar.2019.01522

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Copyright © 2020 Su, Wu, Zhang, Ji, Wang and Tan

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of columbianadin on the fast current (the TTX-S current) and the slow current (the TTX-R current) in small dorsal root ganglion (DRG) neurons. (A) Representative total, TTX-S and TTX-R current recorded from a small DRG neuron in the absence of any compound. (B–C) Representative total, TTX-S and TTX-R current in the presence of 100 μM columbianadin (CBN) or 100 μM osthole (OST), respectively. Recordings are all from independent cells and each cell is only used for a single treatment. (D–E) Current density of TTX-S and TTX-R current in control, CBN and OST groups. Data were presented as mean ± SEM. One-way ANOVA with Tukey's multiple comparisons test.