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. 2020 Jan 9;10:1522. doi: 10.3389/fphar.2019.01522

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Copyright © 2020 Su, Wu, Zhang, Ji, Wang and Tan

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Dose-dependent effects of columbianadin (CBN) and osthole (OST) on oxaliplatin-induced mechanical allodynia and cold hyperalgesia. Effects of treatments (CBN or OST) on pain behaviors were tested 3 days after oxaliplatin administration. CBN and OST dose-dependently attenuated oxaliplatin-induced mechanical and cold pain behaviors. Values are represented as mean± SEM. *p < 0.05, **p < 0.01, vs. vehicle, two-way repeated ANOVA followed by post hoc Bonferroni analysis. N = 6 mice per group.