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. 2020 Jan 9;10:1522. doi: 10.3389/fphar.2019.01522

Figure 7.

Figure 7

Effect of columbianadin (CBN) or osthole (OST) on the I–V current of Ica in the presence of N-type Ica blocker ω-Conotoxin MVIIA in small dorsal root ganglion (DRG) neurons. (A) Representative whole-cell Ica in the presence of 1 μM ω-Conotoxin MVIIA (ω-CNTX) recorded from a small DRG neuron in the absence of any compound. (B) Representative Ica in the presence of 1 μM ω-Conotoxin MVIIA and 100 μM CBN. (C) Representative Ica in the presence of 1 μM ω-Conotoxin MVIIA and 100 μM OST. Recordings are all from independent cells and each cell is only used for a single treatment. (D) Current-voltage relationships of the Ica in ω-Conotoxin MVIIA (black line), during exposure 100 μM OST (blue line) and 100 μM CBN (red line). Data points are mean ± SEM. *p < 0.05, **p < 0.01, vs. ω-Conotoxin MVIIA, two-way repeated ANOVA followed by post hoc Bonferroni analysis.