Table 1.
Characteristics of Patients Included in the Study
| Parameters | All Patients | Good Sleep | Bad Sleep | Odds Ratio (95% CI) |
P-value |
|---|---|---|---|---|---|
| N | 404 | 167 | 237 | ||
| Age – median (range), yearsa | 66 (23–93) | 66 (23–89) | 67 (28–93) | 1.20 (0.80–1.78) | 0.419 |
| Sex – Men N (%) | 239 (59.2) | 97 (58.1) | 142 (59.9) | 0.93 (0.62–1.39) | 0.758 |
| Marital Status N (%) | |||||
| Married | 283 (70.0) | 116 (69.5) | 167 (70.5) | 0.95 (0.62–1.47) | 0.829 |
| Divorced | 53 (13.1) | 17 (10.2) | 36 (15.2) | 0.63 (0.34–1.17) | 0.178 |
| Single | 22 (5.4) | 12 (7.2) | 10 (4.2) | 1.76 (0.74–4.17) | 0.265 |
| Widowed | 46 (11.4) | 22 (13.2) | 24 (10.1) | 1.35 (0.73–2.49) | 0.345 |
| Stage of Diseaseb N (%) | |||||
| I | 45 (11.1) | 25 (15.0) | 20 (8.4) | 1.91 (1.02–3.57) | 0.053 |
| II | 43 (10.6) | 20 (12.0) | 23 (9.7) | 1.26 (0.67–2.39) | 0.514 |
| III | 86 (21.3) | 37 (22.2) | 49 (20.7) | 1.09 (0.67–1.77) | 0.805 |
| IV | 230 (56.9) | 85 (50.9) | 145 (61.2) | 0.66 (0.44–0.98) | 0.042 |
| Pathologic Subtype N (%) | |||||
| NSCLC –Adenocarcinoma | 241 (59.7) | 102 (61.1) | 139 (58.6) | 1.10 (0.74–1.66) | 0.681 |
| NSCLC – Squamous cell | 66 (16.3) | 25 (15.0) | 41 (17.3) | 0.84 (0.49–1.45) | 0.586 |
| NSCLC – NOS | 32 (7.9) | 10 (6.0) | 22 (9.3) | 0.62 (0.29–1.35) | 0.265 |
| NSCLC – Large cell neuroendocrine | 10 (2.5) | 5 (3.0) | 5 (2.1) | 1.29 (0.70–2.37) | 0.434 |
| SCLC | 37 (9.2) | 17 (10.2) | 20 (8.4) | ||
| Thymoma | 10 (2.5) | 3 (1.8) | 7 (3.0) | 1.14 (0.44–2.96) | 0.810 |
| Mesothelioma | 5 (1.2) | 2 (1.2) | 3 (1.3) | ||
| Carcinoid | 3 (0.7) | 3 (1.8) | - | ||
| ECOG PS N (%) | |||||
| 0 | 219 (54.2) | 104 (62.3) | 115 (48.5) | 1.75 (1.17–2.62) | 0.008 |
| 1 | 103 (25.5) | 36 (21.6) | 67 (28.3) | 0.70 (0.44–1.11) | 0.134 |
| 2 | 45 (11.1) | 14 (8.4) | 31 (13.1) | 0.61 (0.31–1.18) | 0.151 |
| 3 | 28 (6.9) | 10 (6.0) | 18 (7.6) | 0.75 (0.37–1.52) | 0.486 |
| 4 | 9 (2.2) | 3 (1.8) | 6 (2.5) | ||
| Smoking – yes | 288 (71.3) | 110 (65.9) | 178 (75.1) | 0.66 (0.42–1.02) | 0.073 |
| Pain – yesa | 183 (45.3) | 50 (29.9) | 133 (56.1) | 2.99 (1.97–4.55) | <0.001 |
| Distress – yesa | 344 (85.1) | 117 (70.1) | 227 (95.8) | 9.70 (4.75–19.82) | <0.001 |
Notes: aCategorial as described in methods; bAJCC version 8th. Data regarding all of the study cohort together, followed by separate columns for patients reporting good sleep or bad sleep (difficulty falling asleep and/or frequent awakening). The odds ratio and the p-value are demonstrated for each factor.
Abbreviations: NS, non-significant; NOS, non-other specified; ECOG-PS, Eastern Cooperative Oncology Group performance status.