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. 2020 Jan 15;13:435–450. doi: 10.2147/OTT.S228702

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© 2020 Saleem et al.

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Effect of Brv-A on cell migration. (A) Cells were cultured in 6-well plate and allowed to attain 90% confluence. Scratch assay/wound healing assay was done to determine effect of Brv-A on migration in MCF-7 cells. Scratched wounds were observed and photographed in control and treated groups after 0, 12 and 24 h by using Leica, DMIL 4000B microscope. Scale bar is 100 µm. (B) Scale was used to measure width (cm) of scratch in control and treated groups. (C) MCF-7 cells were treated with Brv-A for 24 h and expression of COX-2 and MMP-2 was measured by immunoblotting. GAPDH was used as loading control. Graphical data in (B, C) are expressed as Mean ± SD while all experiments were performed in triplicate independently. *p <0.05, **p <0.01, ***p <0.001 vs untreated group (control).