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HC104A and HC106A inhibit DosRST reporter fluorescence. (a) Chemical structures of HC104A and HC106A. HC104A (b) and HC106A (c) inhibited DosR-driven GFP fluorescence signal in a dose-dependent manner, while having minimal impact of Mtb growth (OD, optical density). The EC50 values of fluorescence inhibition for HC104A and HC106A are 9.8 μM and 2.5 μM, respectively.
