Figure 6.

Synergistic interactions between DosRST inhibitors. CDC1551 (hspX’::GFP) was treated with pairwise combinations of two compounds at concentrations of 50 μM to 0.08 μM. GFP fluorescence was measured and used to calculate percentage inhibition. The combination index (CI) for the panel of each drug combination is presented, including (a) artemisinin and HC102A; (b) artemisinin and HC103A; (c) artemisinin and HC104A; and (d) artemisinin and HC106A. Example EC₅₀ curves are presented with individual compounds or a selected synergistic combination to illustrate the potentiating interactions.