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Brain viscoelasticity in EAE and control mice. (A) EAE clinical course of SJL mice immunized with PLP. EAE mice reached the maximal score at day 12–14 after immunization, mean with SEM. At days of expected peak disease, EAE mice showed significant reductions of (B) magnitude modulus, (C) storage and (D) loss modulus, compared to healthy controls. (E) No alteration of the phase angle was observed in EAE mice. Unpaired two-tailed t-test, *p < 0.05, mean ± SD.
