Figure 2.

Comparisons of regional brain viscoelasticity. (A) Sagittal views of an EAE mouse brain showing a representative magnitude image with definitions of the cerebrum/anterior (red) and cerebellum/posterior (blue) regions (1), a wave (deflection) image (2) and a map of the complex modulus superimposed on the magnitude image (3). (B) Comparison of the viscoelastic properties of the posterior/cerebellar region with the anterior region and the whole brain during inflammation. Repeated measures ANOVA, *p < 0.05, **p < 0.01, ***p < 0.001. (C) Delta MRE values at the time of the expected disease peak normalized to the values of age- and gender-matched healthy animals. The magnitude modulus—i.e., the tissue rigidity—is particularly diminished in the posterior region (cerebellum) compared to the anterior region (cerebrum). Data from five independent experiments n = 25. Paired two-tailed t-test, *p < 0.05, mean ± SD.