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. 2020 Jan 13;10:1382. doi: 10.3389/fneur.2019.01382

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Copyright © 2020 Wang, Millward, Hanke-Vela, Malla, Pilch, Gil-Infante, Waiczies, Mueller, Boehm-Sturm, Guo, Sack and Infante-Duarte.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Comparison of whole brain contrast-enhancing lesion burden with whole brain viscoelasticity. (A) Representative T1-weighted MR images pre- (left) and post- (right) GBCA administration. A diffuse contrast-enhancing lesion is seen in the cerebellum (arrow). T1 map pre- and post-contrast with T1 relaxation time in ms. Scale bar = 5 mm. (B) Delta T1 (mean pre-contrast minus mean post-contrast) did not correlate with the magnitude modulus (Pearson correlation, p = 0.8797, r = 0.05181). (C) T1 signal intensity changes (SI%) obtained from the T1-weighted images following Gd application showed no correlation with the magnitude modulus (Pearson correlation, p = 0.3402, r = 0.2315). (D) There was no significant correlation between SI% and the EAE score (Spearman correlation, p = 0.2325, r = −0.4195). Data from two independent experiments, n = 11 and n = 19 in (B–D), respectively.