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. 2020 Jan 13;9:1426. doi: 10.3389/fonc.2019.01426

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Copyright © 2020 Li, Weng, Zhong, Tang, Zhu, Cheng, Xu and Yuan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Decision curve analysis for the competing risks nomogram for 15-year second primary cancer risks in the validation cohort. The X-axis is the risk threshold probability that changes from 0 to 1 (right truncated at 0.25) and the Y-axis is the calculated net benefit for a given threshold probability. The dashed lines depict the net clinical benefit of the competing risks–based selection strategy for intervention, whereas the gray and black curves display the net benefits in the alternative strategies of treating all patients (gray) vs. treating no patients (black) in the cohort.