TABLE 1.
Main Demographic, Neurologic, Psychiatric, APOE Genotype, and TBI History of 4 Military-EOD Cases
| Case ID | Sex | Race | APOE | Impact TBI | Blast TBI | War Experiences/Combat Settings/Military Training | Contact Sport Practice | Dementia onset (Age) | Age at Death | Neurologic Diagnoses | Psychiatric Diagnoses | Family History for Neurologic or Psychiatric Conditions | Cause of Death |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| #1 | M | W | E3/E3 | Yes (LOC during training; MVA at 46) | Unknown/possible | Yes | Yes (not professional, boxing at the Naval academy) | 59 (formal diagnosis) 48 (initial deficits) | 72 | Dementia (atypical AD) | Not reported | Not reported | Cardio-respiratory arrest |
| #2 | M | W | E3/E4 | Yes (Vietnam war; major trauma at 59) | Unknown/possible | Yes (Vietnam) | No | ∼60 | 66 | Alcoholism | Depression; possible maniac episodes | Not reported | Suicide |
| #3 | M | W | E3/E3 | Yes (during each of the 3 deployment periods) | Yes (3 episodes reported) | Yes (Northern Ireland 1980, Sierra Leone 1990, Balkans 1993) | No | 52 | 64 | Dementia (mixed probable AD/vascular dementia) | PTSD | Not reported | Bowel perforation; Multi-organ failure; sepsis, |
| #4 | M | W | E3/E3 | Yes (MVA at 35) | No | Yes (Vietnam) | No | 50 | 63 | Dementia (possible bv FTD [Pick disease]; atypical AD) | Suicide attempt (age 66) | Not reported | Cardio-respiratory arrest |
| 52.5±5.2 | 66.0±3.5 |
The table summarizes the main demographic, APOE genotype, and clinical data of 4 early-onset dementia (EOD) cases among military and war veterans.
LOC, loss of consciousness; MVA, motor vehicle accident; PTSD, post-traumatic stress disorder; AD, Alzheimer’s disease; bv-FTD, behavioral variant-frontotemporal dementia; M, male; W, white; E3, APOE3; E4, APOE4.