TABLE 2.
Main Brain Autopsy and Neuropathologic Data of 4 Military-EOD Cases
| CaseID | BW (g) | PMI (hours) | Cortical Atrophy | AD Pathology | PART | ARTAG | CTE | Lewy Body Pathology | Pigmented Loss SNc/LC | Vascular Pathology (Ischemia/Hypoxia/Hemorrhage) | Myelin Loss (LFB) | Astrogliosis (GFAP) | Microgliosis (Iba-1) | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CERAD | Braak | ABC | Level of AD neuropathologic changes | |||||||||||||
| #1 | 920.0 | N/A | Yes | C | VI | A3B3C3 | High | No | No | Yes | No | No/No | Yes | Yes | Yes | Yes |
| #2 | 1242.18 | N/A | No | C | VI | A2B3C3 | Intermediate | No | Yes | Yes | No | No/No | No | No | Yes | Yes |
| #3 | 1182.59 | N/A | Yes | C | VI | A2B3C3 | Intermediate | No | No | No | No | No/No | No | No | Yes | Yes |
| #4 | 827.0 | N/A | Yes | 0 | VI | A0B3C0 | Low | Yes | Yes | No | No | No/No | No | No | Yes | Yes |
| 1042.9±200.7 | ||||||||||||||||
The table summarizes the main neuropathologic data of each EOD case analyzed in this study.
BW, brain weight (in grams); PMI, postmortem interval (in hours); AD-pathology, Alzheimer’s disease pathology; PART, primary aging-related tauopathy; ARTAG, aging-related tau astrogliopathy; CTE, chronic traumatic encephalopathy; LFB, Luxol fast blue stain; GFAP, antiglial fibrillary acidic protein antibody; Iba-1, anti-ionized calcium binding adaptor molecule 1 antibody; SNc, substantia nigra pars compacta; LC, locus coeruleus.